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So does mirtazepine which is a serotonin norepinephrine enhancer with a strong anti-histamine effect. Seroquel is not an antidepressant, it's an antipsychotic.

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It is at least as effective as the older antidepressants for treating mild to severe depression. Although agranulocytosis is the most serious side effect, it is rare (approximately one in 1,000) and usually reversible when the medication is stopped. Many clinicians consider mirtazapine a second-line or even third-line antidepressant, to be used when older antidepressants are not tolerated or are ineffective.The goal in such development is to produce agents that are more efficacious, safer and better tolerated than older medications. Although all SSRI drugs have the same mechanism of action, each SSRI has slightly different pharmacological and pharmacokinetic characteristics.This leads to differences among the SSRIs in their half-lives, clinical activity, side effects, and drug interactions.Side effects of Mirtazapine As with all antidepressants, there are certain side effects associated with Mirtazapine use.These include weight gain and, because the drug remains in one’s system throughout the course of the day, a person might also experience drowsiness. Acute effects of mirtazapine on sleep continuity and sleep architecture in depressed patients: a pilot study.It enhances central noradrenergic and serotonergic activity by blocking alpha10Mirtazapine is well absorbed without regard to food intake.